1NH3

Human Topoisomerase I Ara-C Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3'	polymer	10	3017.0	1
2	C	5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3'	polymer	12	3564.4	1
3	D	5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3'	polymer	22	6580.1	1
4	A	DNA topoisomerase I	polymer	563	66733.9	1	UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) In PDB	Homo sapiens (human)
5		water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 203 - 765 (UniProt: P11387)

PDB	External Database	Details
Met 699	-	initiating methionine
Ptr 723	Tyr 722	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79895.4
All*	Total formula weight	79895.4

*Water molecules are not included.