1NH3
Human Topoisomerase I Ara-C Complex
Summary for 1NH3
Entry DOI | 10.2210/pdb1nh3/pdb |
Related | 1A31 1EJ9 1K4T 1LPQ |
Descriptor | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3', 5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3', ... (5 entities in total) |
Functional Keywords | ara-c, protein-dna complex, dna damage, isomerase, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus: P11387 |
Total number of polymer chains | 4 |
Total formula weight | 79895.37 |
Authors | Chrencik, J.E.,Burgin, A.B.,Pommier, Y.,Stewart, L.,Redinbo, M.R. (deposition date: 2002-12-18, release date: 2003-03-04, Last modification date: 2023-11-15) |
Primary citation | Chrencik, J.E.,Burgin, A.B.,Pommier, Y.,Stewart, L.,Redinbo, M.R. Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex J.Biol.Chem., 278:12461-12466, 2003 Cited by PubMed: 12533542DOI: 10.1074/jbc.M212930200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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