1NDO

NAPHTHALENE 1,2-DIOXYGENASE

1NDO の概要

• エントリーDOI: 10.2210/pdb1ndo/pdb
• 分子名称: NAPHTHALENE 1,2-DIOXYGENASE, FE (III) ION, FE2/S2 (INORGANIC) CLUSTER, ... (5 entities in total)
• 機能のキーワード: non-heme iron dioxygenase
• 由来する生物種: Pseudomonas putida; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 218595.32

構造登録者

Ramaswamy, S.,Kauppi, B.,Carredano, E. (登録日: 1998-01-11, 公開日: 1999-03-23, 最終更新日: 2024-02-14)

主引用文献

Kauppi, B.,Lee, K.,Carredano, E.,Parales, R.E.,Gibson, D.T.,Eklund, H.,Ramaswamy, S.
Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase.
Structure, 6:571-586, 1998

PubMed Abstract: Pseudomonas sp. NCIB 9816-4 utilizes a multicomponent enzyme system to oxidize naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The enzyme component catalyzing this reaction, naphthalene 1,2-dioxygenase (NDO), belongs to a family of aromatic-ring-hydroxylating dioxygenases that oxidize aromatic hydrocarbons and related compounds to cis-arene diols. These enzymes utilize a mononuclear non-heme iron center to catalyze the addition of dioxygen to their respective substrates. The present study was conducted to provide essential structural information necessary for elucidating the mechanism of action of NDO.

PubMed: 9634695
DOI: 10.1016/S0969-2126(98)00059-8

実験手法

X-RAY DIFFRACTION (2.25 Å)