1MZC

Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a

1MZC の概要

• エントリーDOI: 10.2210/pdb1mzc/pdb
• 関連するPDBエントリー: 1JCQ 1LD7 1LD8
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: Protein Farnesyltransferase alpha Subunit, Protein Farnesyltransferase beta Subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: alpha-alpha barrel, inhibitor, ftase, pftase, fpp, caax, ras, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94948.87

構造登録者

deSolms, S.J.,Ciccarone, T.M.,MacTough, S.C.,Shaw, A.W.,Buser, C.A.,Ellis-Hutchings, M.,Fernandes, C.,Hamilton, K.A.,Huber, H.E.,Kohl, N.E.,Lobell, R.B.,Robinson, R.G.,Tsou, N.N.,Walsh, E.S.,Graham, S.L.,Beese, L.S.,Taylor, J.S. (登録日: 2002-10-07, 公開日: 2003-07-08, 最終更新日: 2024-02-14)

• 主引用文献: DeSolms, S.J.,Ciccarone, T.M.,MacTough, S.C.,Shaw, A.W.,Buser, C.A.,Ellis-Hutchings, M.,Fernandes, C.,Hamilton, K.A.,Huber, H.E.,Kohl, N.E.,Lobell, R.B.,Robinson, R.G.,Tsou, N.N.,Walsh, E.S.,Graham, S.L.,Beese, L.S.,Taylor, J.S.; Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.; J.Med.Chem., 46:2973-2984, 2003; PubMed: 12825937; DOI: 10.1021/jm020587n

実験手法

X-RAY DIFFRACTION (2 Å)