1MXF

Crystal Structure of Inhibitor Complex of Putative Pteridine Reductase 2 (PTR2) from Trypanosoma cruzi

Summary for 1MXF

Entry DOI	10.2210/pdb1mxf/pdb
Related	1E7W 1E92
Descriptor	PTERIDINE REDUCTASE 2, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total)
Functional Keywords	sdr topology, protein-inhibitor complex, oxidoreductase
Biological source	Trypanosoma cruzi
Total number of polymer chains	4
Total formula weight	122087.27
Authors	Schormann, N.,Pal, B.,Senkovich, O.,Carson, M.,Howard, A.,Smith, C.,Delucas, L.,Chattopadhyay, D. (deposition date: 2002-10-02, release date: 2003-10-14, Last modification date: 2017-10-11)
Primary citation	Schormann, N.,Pal, B.,Senkovich, O.,Carson, M.,Howard, A.,Smith, C.,Delucas, L.,Chattopadhyay, D. Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor. J.Struct.Biol., 152:64-75, 2005 Cited by PubMed: 16168672 DOI: 10.1016/j.jsb.2005.07.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation