1MX9

Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue

Summary for 1MX9

• Entry DOI: 10.2210/pdb1mx9/pdb
• Related: 1MX1 1MX5
• Descriptor: liver Carboxylesterase I, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5A,17R)-4,5-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXO-17-(2-PROPENYL)-MORPHINANIUM, ... (4 entities in total)
• Functional Keywords: esterase, hydrolase, heroin
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 733120.55

Authors

Bencharit, S.,Morton, C.L.,Xue, Y.,Potter, P.M.,Redinbo, M.R. (deposition date: 2002-10-01, release date: 2003-04-08, Last modification date: 2020-07-29)

• Primary citation: Bencharit, S.,Morton, C.L.,Xue, Y.,Potter, P.M.,Redinbo, M.R.; Structural Basis of Heroin and Cocaine Metabolism by a Promiscuous Human Drug-Processing Enzyme; Nat.Struct.Biol., 10:349-356, 2003; PubMed: 12679808; DOI: 10.1038/nsb919

Experimental method

X-RAY DIFFRACTION (2.9 Å)