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1MX9

Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue

Functional Information from GO Data
ChainGOidnamespacecontents
A0004771molecular_functionsterol esterase activity
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006695biological_processcholesterol biosynthetic process
A0008203biological_processcholesterol metabolic process
A0009636biological_processresponse to toxic substance
A0010875biological_processpositive regulation of cholesterol efflux
A0010887biological_processnegative regulation of cholesterol storage
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0030855biological_processepithelial cell differentiation
A0042632biological_processcholesterol homeostasis
A0043691biological_processreverse cholesterol transport
A0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
A0051791biological_processmedium-chain fatty acid metabolic process
A0052689molecular_functioncarboxylic ester hydrolase activity
A0070857biological_processregulation of bile acid biosynthetic process
A0071397biological_processcellular response to cholesterol
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
A0090205biological_processpositive regulation of cholesterol metabolic process
A0106435molecular_functioncarboxylesterase activity
A0120188biological_processregulation of bile acid secretion
B0004771molecular_functionsterol esterase activity
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006695biological_processcholesterol biosynthetic process
B0008203biological_processcholesterol metabolic process
B0009636biological_processresponse to toxic substance
B0010875biological_processpositive regulation of cholesterol efflux
B0010887biological_processnegative regulation of cholesterol storage
B0016042biological_processlipid catabolic process
B0016787molecular_functionhydrolase activity
B0030855biological_processepithelial cell differentiation
B0042632biological_processcholesterol homeostasis
B0043691biological_processreverse cholesterol transport
B0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
B0051791biological_processmedium-chain fatty acid metabolic process
B0052689molecular_functioncarboxylic ester hydrolase activity
B0070857biological_processregulation of bile acid biosynthetic process
B0071397biological_processcellular response to cholesterol
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
B0090205biological_processpositive regulation of cholesterol metabolic process
B0106435molecular_functioncarboxylesterase activity
B0120188biological_processregulation of bile acid secretion
C0004771molecular_functionsterol esterase activity
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005788cellular_componentendoplasmic reticulum lumen
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006695biological_processcholesterol biosynthetic process
C0008203biological_processcholesterol metabolic process
C0009636biological_processresponse to toxic substance
C0010875biological_processpositive regulation of cholesterol efflux
C0010887biological_processnegative regulation of cholesterol storage
C0016042biological_processlipid catabolic process
C0016787molecular_functionhydrolase activity
C0030855biological_processepithelial cell differentiation
C0042632biological_processcholesterol homeostasis
C0043691biological_processreverse cholesterol transport
C0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
C0051791biological_processmedium-chain fatty acid metabolic process
C0052689molecular_functioncarboxylic ester hydrolase activity
C0070857biological_processregulation of bile acid biosynthetic process
C0071397biological_processcellular response to cholesterol
C0071404biological_processcellular response to low-density lipoprotein particle stimulus
C0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
C0090205biological_processpositive regulation of cholesterol metabolic process
C0106435molecular_functioncarboxylesterase activity
C0120188biological_processregulation of bile acid secretion
D0004771molecular_functionsterol esterase activity
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005788cellular_componentendoplasmic reticulum lumen
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006695biological_processcholesterol biosynthetic process
D0008203biological_processcholesterol metabolic process
D0009636biological_processresponse to toxic substance
D0010875biological_processpositive regulation of cholesterol efflux
D0010887biological_processnegative regulation of cholesterol storage
D0016042biological_processlipid catabolic process
D0016787molecular_functionhydrolase activity
D0030855biological_processepithelial cell differentiation
D0042632biological_processcholesterol homeostasis
D0043691biological_processreverse cholesterol transport
D0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
D0051791biological_processmedium-chain fatty acid metabolic process
D0052689molecular_functioncarboxylic ester hydrolase activity
D0070857biological_processregulation of bile acid biosynthetic process
D0071397biological_processcellular response to cholesterol
D0071404biological_processcellular response to low-density lipoprotein particle stimulus
D0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
D0090205biological_processpositive regulation of cholesterol metabolic process
D0106435molecular_functioncarboxylesterase activity
D0120188biological_processregulation of bile acid secretion
E0004771molecular_functionsterol esterase activity
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0005788cellular_componentendoplasmic reticulum lumen
E0005811cellular_componentlipid droplet
E0005829cellular_componentcytosol
E0006629biological_processlipid metabolic process
E0006695biological_processcholesterol biosynthetic process
E0008203biological_processcholesterol metabolic process
E0009636biological_processresponse to toxic substance
E0010875biological_processpositive regulation of cholesterol efflux
E0010887biological_processnegative regulation of cholesterol storage
E0016042biological_processlipid catabolic process
E0016787molecular_functionhydrolase activity
E0030855biological_processepithelial cell differentiation
E0042632biological_processcholesterol homeostasis
E0043691biological_processreverse cholesterol transport
E0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
E0051791biological_processmedium-chain fatty acid metabolic process
E0052689molecular_functioncarboxylic ester hydrolase activity
E0070857biological_processregulation of bile acid biosynthetic process
E0071397biological_processcellular response to cholesterol
E0071404biological_processcellular response to low-density lipoprotein particle stimulus
E0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
E0090205biological_processpositive regulation of cholesterol metabolic process
E0106435molecular_functioncarboxylesterase activity
E0120188biological_processregulation of bile acid secretion
F0004771molecular_functionsterol esterase activity
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005788cellular_componentendoplasmic reticulum lumen
F0005811cellular_componentlipid droplet
F0005829cellular_componentcytosol
F0006629biological_processlipid metabolic process
F0006695biological_processcholesterol biosynthetic process
F0008203biological_processcholesterol metabolic process
F0009636biological_processresponse to toxic substance
F0010875biological_processpositive regulation of cholesterol efflux
F0010887biological_processnegative regulation of cholesterol storage
F0016042biological_processlipid catabolic process
F0016787molecular_functionhydrolase activity
F0030855biological_processepithelial cell differentiation
F0042632biological_processcholesterol homeostasis
F0043691biological_processreverse cholesterol transport
F0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
F0051791biological_processmedium-chain fatty acid metabolic process
F0052689molecular_functioncarboxylic ester hydrolase activity
F0070857biological_processregulation of bile acid biosynthetic process
F0071397biological_processcellular response to cholesterol
F0071404biological_processcellular response to low-density lipoprotein particle stimulus
F0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
F0090205biological_processpositive regulation of cholesterol metabolic process
F0106435molecular_functioncarboxylesterase activity
F0120188biological_processregulation of bile acid secretion
G0004771molecular_functionsterol esterase activity
G0005737cellular_componentcytoplasm
G0005783cellular_componentendoplasmic reticulum
G0005788cellular_componentendoplasmic reticulum lumen
G0005811cellular_componentlipid droplet
G0005829cellular_componentcytosol
G0006629biological_processlipid metabolic process
G0006695biological_processcholesterol biosynthetic process
G0008203biological_processcholesterol metabolic process
G0009636biological_processresponse to toxic substance
G0010875biological_processpositive regulation of cholesterol efflux
G0010887biological_processnegative regulation of cholesterol storage
G0016042biological_processlipid catabolic process
G0016787molecular_functionhydrolase activity
G0030855biological_processepithelial cell differentiation
G0042632biological_processcholesterol homeostasis
G0043691biological_processreverse cholesterol transport
G0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
G0051791biological_processmedium-chain fatty acid metabolic process
G0052689molecular_functioncarboxylic ester hydrolase activity
G0070857biological_processregulation of bile acid biosynthetic process
G0071397biological_processcellular response to cholesterol
G0071404biological_processcellular response to low-density lipoprotein particle stimulus
G0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
G0090205biological_processpositive regulation of cholesterol metabolic process
G0106435molecular_functioncarboxylesterase activity
G0120188biological_processregulation of bile acid secretion
H0004771molecular_functionsterol esterase activity
H0005737cellular_componentcytoplasm
H0005783cellular_componentendoplasmic reticulum
H0005788cellular_componentendoplasmic reticulum lumen
H0005811cellular_componentlipid droplet
H0005829cellular_componentcytosol
H0006629biological_processlipid metabolic process
H0006695biological_processcholesterol biosynthetic process
H0008203biological_processcholesterol metabolic process
H0009636biological_processresponse to toxic substance
H0010875biological_processpositive regulation of cholesterol efflux
H0010887biological_processnegative regulation of cholesterol storage
H0016042biological_processlipid catabolic process
H0016787molecular_functionhydrolase activity
H0030855biological_processepithelial cell differentiation
H0042632biological_processcholesterol homeostasis
H0043691biological_processreverse cholesterol transport
H0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
H0051791biological_processmedium-chain fatty acid metabolic process
H0052689molecular_functioncarboxylic ester hydrolase activity
H0070857biological_processregulation of bile acid biosynthetic process
H0071397biological_processcellular response to cholesterol
H0071404biological_processcellular response to low-density lipoprotein particle stimulus
H0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
H0090205biological_processpositive regulation of cholesterol metabolic process
H0106435molecular_functioncarboxylesterase activity
H0120188biological_processregulation of bile acid secretion
I0004771molecular_functionsterol esterase activity
I0005737cellular_componentcytoplasm
I0005783cellular_componentendoplasmic reticulum
I0005788cellular_componentendoplasmic reticulum lumen
I0005811cellular_componentlipid droplet
I0005829cellular_componentcytosol
I0006629biological_processlipid metabolic process
I0006695biological_processcholesterol biosynthetic process
I0008203biological_processcholesterol metabolic process
I0009636biological_processresponse to toxic substance
I0010875biological_processpositive regulation of cholesterol efflux
I0010887biological_processnegative regulation of cholesterol storage
I0016042biological_processlipid catabolic process
I0016787molecular_functionhydrolase activity
I0030855biological_processepithelial cell differentiation
I0042632biological_processcholesterol homeostasis
I0043691biological_processreverse cholesterol transport
I0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
I0051791biological_processmedium-chain fatty acid metabolic process
I0052689molecular_functioncarboxylic ester hydrolase activity
I0070857biological_processregulation of bile acid biosynthetic process
I0071397biological_processcellular response to cholesterol
I0071404biological_processcellular response to low-density lipoprotein particle stimulus
I0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
I0090205biological_processpositive regulation of cholesterol metabolic process
I0106435molecular_functioncarboxylesterase activity
I0120188biological_processregulation of bile acid secretion
J0004771molecular_functionsterol esterase activity
J0005737cellular_componentcytoplasm
J0005783cellular_componentendoplasmic reticulum
J0005788cellular_componentendoplasmic reticulum lumen
J0005811cellular_componentlipid droplet
J0005829cellular_componentcytosol
J0006629biological_processlipid metabolic process
J0006695biological_processcholesterol biosynthetic process
J0008203biological_processcholesterol metabolic process
J0009636biological_processresponse to toxic substance
J0010875biological_processpositive regulation of cholesterol efflux
J0010887biological_processnegative regulation of cholesterol storage
J0016042biological_processlipid catabolic process
J0016787molecular_functionhydrolase activity
J0030855biological_processepithelial cell differentiation
J0042632biological_processcholesterol homeostasis
J0043691biological_processreverse cholesterol transport
J0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
J0051791biological_processmedium-chain fatty acid metabolic process
J0052689molecular_functioncarboxylic ester hydrolase activity
J0070857biological_processregulation of bile acid biosynthetic process
J0071397biological_processcellular response to cholesterol
J0071404biological_processcellular response to low-density lipoprotein particle stimulus
J0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
J0090205biological_processpositive regulation of cholesterol metabolic process
J0106435molecular_functioncarboxylesterase activity
J0120188biological_processregulation of bile acid secretion
K0004771molecular_functionsterol esterase activity
K0005737cellular_componentcytoplasm
K0005783cellular_componentendoplasmic reticulum
K0005788cellular_componentendoplasmic reticulum lumen
K0005811cellular_componentlipid droplet
K0005829cellular_componentcytosol
K0006629biological_processlipid metabolic process
K0006695biological_processcholesterol biosynthetic process
K0008203biological_processcholesterol metabolic process
K0009636biological_processresponse to toxic substance
K0010875biological_processpositive regulation of cholesterol efflux
K0010887biological_processnegative regulation of cholesterol storage
K0016042biological_processlipid catabolic process
K0016787molecular_functionhydrolase activity
K0030855biological_processepithelial cell differentiation
K0042632biological_processcholesterol homeostasis
K0043691biological_processreverse cholesterol transport
K0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
K0051791biological_processmedium-chain fatty acid metabolic process
K0052689molecular_functioncarboxylic ester hydrolase activity
K0070857biological_processregulation of bile acid biosynthetic process
K0071397biological_processcellular response to cholesterol
K0071404biological_processcellular response to low-density lipoprotein particle stimulus
K0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
K0090205biological_processpositive regulation of cholesterol metabolic process
K0106435molecular_functioncarboxylesterase activity
K0120188biological_processregulation of bile acid secretion
L0004771molecular_functionsterol esterase activity
L0005737cellular_componentcytoplasm
L0005783cellular_componentendoplasmic reticulum
L0005788cellular_componentendoplasmic reticulum lumen
L0005811cellular_componentlipid droplet
L0005829cellular_componentcytosol
L0006629biological_processlipid metabolic process
L0006695biological_processcholesterol biosynthetic process
L0008203biological_processcholesterol metabolic process
L0009636biological_processresponse to toxic substance
L0010875biological_processpositive regulation of cholesterol efflux
L0010887biological_processnegative regulation of cholesterol storage
L0016042biological_processlipid catabolic process
L0016787molecular_functionhydrolase activity
L0030855biological_processepithelial cell differentiation
L0042632biological_processcholesterol homeostasis
L0043691biological_processreverse cholesterol transport
L0047374molecular_functionmethylumbelliferyl-acetate deacetylase activity
L0051791biological_processmedium-chain fatty acid metabolic process
L0052689molecular_functioncarboxylic ester hydrolase activity
L0070857biological_processregulation of bile acid biosynthetic process
L0071397biological_processcellular response to cholesterol
L0071404biological_processcellular response to low-density lipoprotein particle stimulus
L0090122biological_processcholesterol ester hydrolysis involved in cholesterol transport
L0090205biological_processpositive regulation of cholesterol metabolic process
L0106435molecular_functioncarboxylesterase activity
L0120188biological_processregulation of bile acid secretion
Functional Information from PROSITE/UniProt
site_idPS00122
Number of Residues16
DetailsCARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGnpgsVtIfGeSAG
ChainResidueDetails
APHE1208-GLY1223

site_idPS00941
Number of Residues11
DetailsCARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIYtP
ChainResidueDetails
AGLU1114-PRO1124

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:12022871
ChainResidueDetails
ASER1221
JSER4221
KSER5221
LSER6221
BSER2221
CSER3221
DSER4221
ESER5221
FSER6221
GSER1221
HSER2221
ISER3221

site_idSWS_FT_FI2
Number of Residues24
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:12022871
ChainResidueDetails
AGLU1354
EGLY5469
FGLU6354
FGLY6469
GGLU1354
GGLY1469
HGLU2354
HGLY2469
IGLU3354
IGLY3469
JGLU4354
AGLY1469
JGLY4469
KGLU5354
KGLY5469
LGLU6354
LGLY6469
BGLU2354
BGLY2469
CGLU3354
CGLY3469
DGLU4354
DGLY4469
EGLU5354

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ALEU1381
JLEU4381
KLEU5381
LLEU6381
BLEU2381
CLEU3381
DLEU4381
ELEU5381
FLEU6381
GLEU1381
HLEU2381
ILEU3381

site_idSWS_FT_FI4
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12022871
ChainResidueDetails
AASN1079
JASN4079
KASN5079
LASN6079
BASN2079
CASN3079
DASN4079
EASN5079
FASN6079
GASN1079
HASN2079
IASN3079

218853

PDB entries from 2024-04-24

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