1MX1

Crystal Structure of Human Liver Carboxylesterase in complex with tacrine

Summary for 1MX1

• Entry DOI: 10.2210/pdb1mx1/pdb
• Related: 1MX5 1MX9
• Descriptor: liver Carboxylesterase I, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: esterase, hydrolase, esterase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 367246.28

Authors

Bencharit, S.,Morton, C.L.,Hyatt, J.L.,Kuhn, P.,Danks, M.K.,Potter, P.M.,Redinbo, M.R. (deposition date: 2002-10-01, release date: 2003-04-22, Last modification date: 2020-07-29)

• Primary citation: Bencharit, S.,Morton, C.L.,Hyatt, J.L.,Kuhn, P.,Danks, M.K.,Potter, P.M.,Redinbo, M.R.; Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: From Binding Promiscuity to Selective Inhibition; CHEM.BIOL., 10:341-349, 2003; PubMed: 12725862; DOI: 10.1016/S1074-5521(03)00071-1

Experimental method

X-RAY DIFFRACTION (2.4 Å)