1MSV

The S68A S-adenosylmethionine decarboxylase proenzyme processing mutant.

Summary for 1MSV

Entry DOI	10.2210/pdb1msv/pdb
Related	1I72 1I76 1I79 1I7B 1I7M 1JEN 1JL0
Descriptor	S-adenosylmethionine decarboxylase proenzyme, 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	spermidine biosynthesis, lyase, decarboxylase, pyruvate, s-adenosylmethionine, sandwich, allosteric enzyme, pyruvoyl
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	81670.79
Authors	Tolbert, W.D.,Zhang, Y.,Bennett, E.M.,Cottet, S.E.,Ekstrom, J.L.,Pegg, A.E.,Ealick, S.E. (deposition date: 2002-09-19, release date: 2003-03-11, Last modification date: 2024-02-14)
Primary citation	Tolbert, W.D.,Zhang, Y.,Cottet, S.E.,Bennett, E.M.,Ekstrom, J.L.,Pegg, A.E.,Ealick, S.E. Mechanism of Human S-Adenosylmethionine Decarboxylase Proenzyme Processing as Revealed by the Structure of the S68A Mutant. Biochemistry, 42:2386-2395, 2003 Cited by PubMed: 12600205 DOI: 10.1021/bi0268854 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation