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1MSV

The S68A S-adenosylmethionine decarboxylase proenzyme processing mutant.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004014molecular_functionadenosylmethionine decarboxylase activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0006595biological_processpolyamine metabolic process
A0006596biological_processpolyamine biosynthetic process
A0006597biological_processspermine biosynthetic process
A0008295biological_processspermidine biosynthetic process
A0016829molecular_functionlyase activity
A0016831molecular_functioncarboxy-lyase activity
A0019810molecular_functionputrescine binding
A0042802molecular_functionidentical protein binding
B0004014molecular_functionadenosylmethionine decarboxylase activity
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0006595biological_processpolyamine metabolic process
B0006596biological_processpolyamine biosynthetic process
B0006597biological_processspermine biosynthetic process
B0008295biological_processspermidine biosynthetic process
B0016829molecular_functionlyase activity
B0016831molecular_functioncarboxy-lyase activity
B0019810molecular_functionputrescine binding
B0042802molecular_functionidentical protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PUT A 355
ChainResidue
ALEU13
AGLU15
APHE111
AASP174
ATHR176
ATYR318
AHOH631
AHOH665
AHOH784

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PUT B 355
ChainResidue
BLEU13
BGLU15
BPHE111
BASP174
BTHR176
BTYR318
BHOH661
BHOH699
BHOH763

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE TRS A 500
ChainResidue
AHIS5
APHE7
AGLU67
ACYS226
APRO246
AGLU247
AHOH672

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE TRS B 501
ChainResidue
BHIS5
BPHE7
BGLU67
BCYS226
BPRO246
BGLU247
BHOH715

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"evidences":[{"source":"PubMed","id":"1917972","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Schiff-base intermediate with substrate; via pyruvic acid","evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"description":"Proton donor; for catalytic activity","evidences":[{"source":"PubMed","id":"10029540","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsActive site: {"description":"Proton acceptor; for processing activity","evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Cleavage (non-hydrolytic); by autolysis","evidences":[{"source":"PubMed","id":"2460457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2687270","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Pyruvic acid (Ser); by autocatalysis","evidences":[{"source":"PubMed","id":"2460457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2687270","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues5
DetailsAnnotated By Reference To The Literature 1jen
ChainResidueDetails
AHIS243
ASER229
ACYS82
BGLU11
BGLU67

site_idCSA2
Number of Residues5
DetailsAnnotated By Reference To The Literature 1jen
ChainResidueDetails
AGLU11
AGLU67
BSER229
BHIS243
BCYS82

site_idMCSA1
Number of Residues5
DetailsM-CSA 575
ChainResidueDetails
AGLU67
AALA68covalently attached, electron shuttle
ACYS82proton shuttle (general acid/base)
ASER229
AHIS243

site_idMCSA2
Number of Residues5
DetailsM-CSA 575
ChainResidueDetails
BGLU67
BALA68covalently attached, electron shuttle
BCYS82proton shuttle (general acid/base)
BSER229
BHIS243

239149

PDB entries from 2025-07-23

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