1MSN

The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor)

Summary for 1MSN

• Entry DOI: 10.2210/pdb1msn/pdb
• Related: 1MRW 1MRX 1MSM
• Related PRD ID: PRD_000566
• Descriptor: POL polyprotein, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide (3 entities in total)
• Functional Keywords: hiv, kni-764, protease, drug target, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22253.37

Authors

Vega, S.,Kang, L.-W.,Velazquez-Campoy, A.,Kiso, Y.,Amzel, L.M.,Freire, E. (deposition date: 2002-09-19, release date: 2003-11-04, Last modification date: 2024-02-14)

• Primary citation: Vega, S.,Kang, L.-W.,Velazquez-Campoy, A.,Kiso, Y.,Amzel, L.M.,Freire, E.; A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease.; Proteins, 55:594-602, 2004; PubMed: 15103623; DOI: 10.1002/prot.20069

Experimental method

X-RAY DIFFRACTION (2 Å)