1MRW
Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577
Summary for 1MRW
Entry DOI | 10.2210/pdb1mrw/pdb |
Related | 1MRX 1MSM 1MSN |
Related PRD ID | PRD_000567 |
Descriptor | POL polyprotein, (4R)-N-tert-butyl-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazoli dine-4-carboxamide (3 entities in total) |
Functional Keywords | hiv, kni-577, protease, drug target, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22137.29 |
Authors | Vega, S.,Kang, L.-W.,Velazquez-Campoy, A.,Kiso, Y.,Amzel, L.M.,Freire, E. (deposition date: 2002-09-18, release date: 2003-11-04, Last modification date: 2024-02-14) |
Primary citation | Vega, S.,Kang, L.-W.,Velazquez-Campoy, A.,Kiso, Y.,Amzel, L.M.,Freire, E. A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease. Proteins, 55:594-602, 2004 Cited by PubMed: 15103623DOI: 10.1002/prot.20069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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