1MSM

The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor)

1MSM の概要

• エントリーDOI: 10.2210/pdb1msm/pdb
• 関連するPDBエントリー: 1MRW 1MRX 1MSN
• 関連するBIRD辞書のPRD_ID: PRD_000566
• 分子名称: POL polyprotein, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide (3 entities in total)
• 機能のキーワード: hiv, kni-764, protease, drug target, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22185.33

構造登録者

Vega, S.,Kang, L.-W.,Velazquez-Campoy, A.,Kiso, Y.,Amzel, L.M.,Freire, E. (登録日: 2002-09-19, 公開日: 2003-11-04, 最終更新日: 2024-02-14)

• 主引用文献: Vega, S.,Kang, L.-W.,Velazquez-Campoy, A.,Kiso, Y.,Amzel, L.M.,Freire, E.; A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease.; Proteins, 55:594-602, 2004; PubMed: 15103623; DOI: 10.1002/prot.20069

実験手法

X-RAY DIFFRACTION (2 Å)