1MSC

CRYSTAL STRUCTURE OF MS2 COAT PROTEIN DIMER

Summary for 1MSC

• Entry DOI: 10.2210/pdb1msc/pdb
• Descriptor: BACTERIOPHAGE MS2 COAT PROTEIN (2 entities in total)
• Functional Keywords: translation repressor, viral protein
• Biological source: Enterobacterio phage MS2
• Cellular location: Virion (Potential): P03612
• Total number of polymer chains: 1
• Total formula weight: 13709.45

Authors

Ni, C.-Z.,Kodandapani, R.,Ely, K.R. (deposition date: 1995-04-28, release date: 1995-07-10, Last modification date: 2024-02-14)

Primary citation

Ni, C.Z.,Syed, R.,Kodandapani, R.,Wickersham, J.,Peabody, D.S.,Ely, K.R.
Crystal structure of the MS2 coat protein dimer: implications for RNA binding and virus assembly.
Structure, 3:255-263, 1995

PubMed Abstract: The coat protein in RNA bacteriophages binds and encapsidates viral RNA, and also acts as translational repressor of viral replicase by binding to an RNA hairpin in the RNA genome. Because of its dual function, the MS2 coat protein is an interesting candidate for structural studies of protein-RNA interactions and protein-protein interactions. In this study, unassembled MS2 coat protein dimers were selected to analyze repressor activity and virus assembly.

PubMed: 7788292
DOI: 10.1016/S0969-2126(01)00156-3

Experimental method

X-RAY DIFFRACTION (2 Å)