1MHP

Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody

Summary for 1MHP

Entry DOI	10.2210/pdb1mhp/pdb
Descriptor	integrin alpha 1, (RESIDUES 169-360), Fab fragment, heavy chain, FAB FRAGMENT, light chain, ... (4 entities in total)
Functional Keywords	integrin, cell adhesion, receptor, antibody, immune system
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Membrane; Single-pass type I membrane protein: P18614
Total number of polymer chains	6
Total formula weight	136056.04
Authors	Karpusas, M.,Taylor, F.,Ferrant, J.,Weinreb, P.,Garber, E. (deposition date: 2002-08-20, release date: 2003-04-15, Last modification date: 2021-10-27)
Primary citation	Karpusas, M.,Ferrant, J.,Weinreb, P.,Carmillo, A.,Taylor, F.,Garber, E. Crystal Structure of the alpha 1 beta 1 Integrin I Domain in Complex with an Antibody Fab Fragment J.Mol.Biol., 327:1031-1041, 2003 Cited by PubMed: 12662928 DOI: 10.1016/S0022-2836(03)00203-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation