1MDW
Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation
Summary for 1MDW
| Entry DOI | 10.2210/pdb1mdw/pdb |
| Related | 1AJ5 1ALW 1DFO 1KFU 1KFX 1KXR |
| Descriptor | Calpain II, catalytic subunit, CALCIUM ION (3 entities in total) |
| Functional Keywords | calpain cysteine protease fold, two cooperative calcium sites, helix instability, tryptophan-based active site blockage, hydrolase |
| Biological source | Rattus norvegicus (Norway rat) |
| Cellular location | Cytoplasm (By similarity): Q07009 |
| Total number of polymer chains | 2 |
| Total formula weight | 73776.27 |
| Authors | Moldoveanu, T.,Hosfield, C.M.,Lim, D.,Jia, Z.,Davies, P.L. (deposition date: 2002-08-07, release date: 2003-04-29, Last modification date: 2024-02-14) |
| Primary citation | Moldoveanu, T.,Hosfield, C.M.,Lim, D.,Jia, Z.,Davies, P.L. Calpain silencing by a reversible intrinsic mechanism. Nat.Struct.Biol., 10:371-378, 2003 Cited by PubMed: 12665854DOI: 10.1038/nsb917 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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