1MDW
Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Calpain II, catalytic subunit | polymer | 328 | 36808.0 | 2 | UniProt (Q07009) Pfam (PF00648) | Rattus norvegicus (Norway rat) | Calcium-activated neutral proteinase, CANP, M-type, M-calpain, Millimolar-calpain |
| 2 | C, D, E, F (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 3 | G, H (A, B) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
A, B: 19 - 346 (UniProt: Q07009)
| PDB | External Database | Details |
|---|---|---|
| Ser 105 | Cys 105 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73616.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 160.3 | |
| All* | Total formula weight | 73776.3 |
