1M6D

Crystal structure of human cathepsin F

1M6D の概要

• エントリーDOI: 10.2210/pdb1m6d/pdb
• 分子名称: Cathepsin F, 4-MORPHOLIN-4-YL-PIPERIDINE-1-CARBOXYLIC ACID [1-(3-BENZENESULFONYL-1-PROPYL-ALLYLCARBAMOYL)-2-PHENYLETHYL]-AMIDE (3 entities in total)
• 機能のキーワード: papain family cysteine protease, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: Q9UBX1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48480.81

構造登録者

Somoza, J.R.,Palmer, J.T.,Ho, J.D. (登録日: 2002-07-15, 公開日: 2003-07-15, 最終更新日: 2024-12-25)

主引用文献

Somoza, J.R.,Palmer, J.T.,Ho, J.D.
The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators
J.Mol.Biol., 322:559-568, 2002

PubMed Abstract: Cathepsin F is a lysosomal cysteine protease of the papain family, and likely plays a regulatory role in processing the invariant chain that is associated with the major histocompatibility complex (MHC) class II. Evidence suggests that inhibiting cathepsin F activity will block MHC class II processing in macrophages. Consequently, inhibitors of this enzyme may be useful in treating certain diseases that involve an inappropriate or excessive immune response. We have determined the 1.7A structure of the mature domain of human cathepsin F associated with an irreversible vinyl sulfone inhibitor. This structure provides a basis for understanding cathepsin F's substrate specificity, and suggests ways of identifying potent and selective inhibitors of this enzyme.

PubMed: 12225749
DOI: 10.1016/S0022-2836(02)00780-5

実験手法

X-RAY DIFFRACTION (1.7 Å)