1M48

Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-L-phenylalanine methyl ester

Summary for 1M48

• Entry DOI: 10.2210/pdb1m48/pdb
• Related: 1M49 1M4A 1M4B 1M4C 1m47
• Descriptor: interleukin-2, 2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3-(4-PHENYLETHYNYL-PHENYL)-PROPIONIC ACID METHYL ESTER (3 entities in total)
• Functional Keywords: interleukin-2, four-helix bundle, small molecule complex, cytokine
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P60568
• Total number of polymer chains: 2
• Total formula weight: 31765.04

Authors

Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. (deposition date: 2002-07-02, release date: 2002-07-31, Last modification date: 2017-10-11)

• Primary citation: Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C.; Binding of small molecules to an adaptive protein-protein interface; Proc.Natl.Acad.Sci.USA, 100:1603-1608, 2003; PubMed: 12582206; DOI: 10.1073/pnas.252756299

Experimental method

X-RAY DIFFRACTION (1.95 Å)