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1M04

Mutant Streptomyces plicatus beta-hexosaminidase (D313N) in complex with product (GlcNAc)

Summary for 1M04
Entry DOI10.2210/pdb1m04/pdb
Related1M01 1M03 1hp5 1jak
DescriptorBeta-N-acetylhexosaminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (6 entities in total)
Functional Keywordssubstrate assisted catalysis, hexosaminidase, family 20 glycosidase, hydrolase
Biological sourceStreptomyces plicatus
Total number of polymer chains1
Total formula weight56641.52
Authors
Williams, S.J.,Mark, B.L.,Vocadlo, D.J.,James, M.N.G.,Withers, S.G. (deposition date: 2002-06-11, release date: 2002-12-11, Last modification date: 2021-10-27)
Primary citationWilliams, S.J.,Mark, B.L.,Vocadlo, D.J.,James, M.N.,Withers, S.G.
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277:40055-40065, 2002
Cited by
PubMed: 12171933
DOI: 10.1074/jbc.M206481200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

數據於2024-03-27公開中

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