1LX6

Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Benzamide Inhibitor

Summary for 1LX6

• Entry DOI: 10.2210/pdb1lx6/pdb
• Related: 1C14 1I2Z 1I30 1QG6 1lxc
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-[(ACETYL-METHYL-AMINO)-METHYL]-4-AMINO-N-METHYL-N-(1-METHYL-1H-INDOL-2-YLMETHYL)-BENZAMIDE, ... (4 entities in total)
• Functional Keywords: fabi, enoyl reductase, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57869.64

Authors

Smith, W.W.,Qiu, X.,Janson, C.A. (deposition date: 2002-06-04, release date: 2002-09-04, Last modification date: 2024-02-14)

• Primary citation: Miller, W.H.,Seefeld, M.A.,Newlander, K.A.,Uzinskas, I.N.,Burgess, W.J.,Heerding, D.A.,Yuan, C.C.,Head, M.S.,Payne, D.J.,Rittenhouse, S.F.,Moore, T.D.,Pearson, S.C.,Berry, V.,DeWolf Jr., W.E.,Keller, P.M.,Polizzi, B.J.,Qiu, X.,Janson, C.A.,Huffman, W.F.; Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).; J.Med.Chem., 45:3246-3256, 2002; PubMed: 12109908; DOI: 10.1021/jm020050+

Experimental method

X-RAY DIFFRACTION (2.4 Å)