1I30

E. Coli Enoyl Reductase +NAD+SB385826

Summary for 1I30

• Entry DOI: 10.2210/pdb1i30/pdb
• Related: 1C14 1I2Z
• Descriptor: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,3,4,9-TETRAHYDRO-2-(HYDROXYBENZOYL)-9-[(4-HYDROXYPHENYL)METHYL]-6-METHOXY-2H-PYRIDO[3,4-B]INDOLE, ... (4 entities in total)
• Functional Keywords: enoyl reductase, acp, antibiotic, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57909.61

Authors

Seefeld, M.A.,Miller, W.H.,Payne, D.J.,Janson, C.A.,Qiu, X. (deposition date: 2001-02-12, release date: 2002-02-12, Last modification date: 2024-02-07)

• Primary citation: Seefeld, M.A.,Miller, W.H.,Newlander, K.A.,Burgess, W.J.,Payne, D.J.,Rittenhouse, S.F.,Moore, T.D.,DeWolf, W.E.,Keller, P.M.,Qiu, X.,Janson, C.A.,Vaidya, K.,Fosberry, A.P.,Smyth, M.G.,Jaworski, D.D.,Slater-Radosti, C.,Huffman, W.F.; Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.; Bioorg.Med.Chem.Lett., 11:2241-2244, 2001; PubMed: 11527706; DOI: 10.1016/S0960-894X(01)00404-8

Experimental method

X-RAY DIFFRACTION (2.4 Å)