1LQB
Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
Summary for 1LQB
Entry DOI | 10.2210/pdb1lqb/pdb |
Descriptor | Elongin B, Elongin C, von hippel-lindau disease tumor supressor, ... (6 entities in total) |
Functional Keywords | protein-peptide complex, tumor suppressor, cancer, proteosomal degradation, ubiquitin, prolyl hydroxylation, gene regulation |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Probable): Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337 Cytoplasm: Q16665 |
Total number of polymer chains | 4 |
Total formula weight | 46768.89 |
Authors | Hon, W.C.,Wilson, M.I.,Harlos, K.,Claridge, T.D.,Schofield, C.J.,Pugh, C.W.,Maxwell, P.H.,Ratcliffe, P.J.,Stuart, D.I.,Jones, E.Y. (deposition date: 2002-05-09, release date: 2002-07-03, Last modification date: 2023-08-16) |
Primary citation | Hon, W.C.,Wilson, M.I.,Harlos, K.,Claridge, T.D.,Schofield, C.J.,Pugh, C.W.,Maxwell, P.H.,Ratcliffe, P.J.,Stuart, D.I.,Jones, E.Y. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature, 417:975-978, 2002 Cited by PubMed: 12050673DOI: 10.1038/nature00767 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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