1LKY

Structure of the wild-type TEL-SAM polymer

Summary for 1LKY

• Entry DOI: 10.2210/pdb1lky/pdb
• Descriptor: TRANSCRIPTION FACTOR ETV6, SULFATE ION, ... (4 entities in total)
• Functional Keywords: leukemia, tyrosine kinase, transcriptional repression, drug design, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P41212 P41212
• Total number of polymer chains: 6
• Total formula weight: 56698.08

Authors

Tran, H.H.,Kim, C.A.,Faham, S.,Bowie, J.U. (deposition date: 2002-04-26, release date: 2002-06-12, Last modification date: 2023-08-16)

Primary citation

Tran, H.H.,Kim, C.A.
Native interface of the SAM domain polymer of TEL.
BMC STRUCT.BIOL., 2:5-5, 2002

PubMed Abstract: TEL is a transcriptional repressor containing a SAM domain that forms a helical polymer. In a number of hematologic malignancies, chromosomal translocations lead to aberrant fusions of TEL-SAM to a variety of other proteins, including many tyrosine kinases. TEL-SAM polymerization results in constitutive activation of the tyrosine kinase domains to which it becomes fused, leading to cell transformation. Thus, inhibitors of TEL-SAM self-association could abrogate transformation in these cells. In previous work, we determined the structure of a mutant TEL-SAM polymer bearing a Val to Glu substitution in center of the subunit interface. It remained unclear how much the mutation affected the architecture of the polymer, however.

PubMed: 12193272
DOI: 10.1186/1472-6807-2-5

Experimental method

X-RAY DIFFRACTION (2.3 Å)