1LF2

CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR RS370

Summary for 1LF2

Related1LFE 1LF3 1LF4
DescriptorPlasmepsin 2, 3-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE (3 entities in total)
Functional Keywordsplasmepsin, plasmodium falciparum, aspartic protease, hydrolase
Biological sourcePlasmodium falciparum (malaria parasite P. falciparum)
Cellular locationVacuole P46925
Total number of polymer chains1
Total molecular weight37611.51
Authors
Asojo, O.A.,Afonina, E.,Gulnik, S.V.,Yu, B.,Erickson, J.W.,Randad, R.,Mehadjed, D.,Silva, A.M. (deposition date: 2002-04-10, release date: 2002-10-10, Last modification date: 2011-07-13)
Primary citation
Asojo, O.A.,Afonina, E.,Gulnik, S.V.,Yu, B.,Erickson, J.W.,Randad, R.,Medjahed, D.,Silva, A.M.
Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
Acta Crystallogr.,Sect.D, 58:2001-2008, 2002
PubMed: 12454457 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444902014695
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27513 1.5% 5.1% 6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02