1L2I

Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide

Summary for 1L2I

Entry DOI	10.2210/pdb1l2i/pdb
Related	1L2J 3ERD
Descriptor	ESTROGEN RECEPTOR, GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	nuclear receptor, transcription factor, estrogen, agonist, coactivator, transcription receptor-coactivator complex, transcription receptor/coactivator
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	63652.55
Authors	Shiau, A.K.,Barstad, D.,Radek, J.T.,Meyers, M.J.,Nettles, K.W.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Agard, D.A.,Greene, G.L. (deposition date: 2002-02-21, release date: 2002-05-01, Last modification date: 2023-08-16)
Primary citation	Shiau, A.K.,Barstad, D.,Radek, J.T.,Meyers, M.J.,Nettles, K.W.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Agard, D.A.,Greene, G.L. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nat.Struct.Biol., 9:359-364, 2002 Cited by PubMed: 11953755 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation