1L2I
Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ESTROGEN RECEPTOR | polymer | 261 | 29908.3 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER-ALPHA, OESTROGEN RECEPTOR ALPHA |
| 2 | C, D (C, D) | GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1 | polymer | 13 | 1579.9 | 2 | UniProt (Q61026) | NUCLEAR RECEPTOR COACTIVATOR 2, GRIP1 | |
| 3 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | F, G (A, B) | (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL | non-polymer | 320.4 | 2 | Chemie (ETC) | |||
| 5 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A, B: 297 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | cloning artifact |
| Asp 295 | - | cloning artifact |
| Pro 296 | - | cloning artifact |
| Ccs 417 | Cys 417 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62976.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 676.3 | |
| All* | Total formula weight | 63652.5 |
