1L2I
Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 601 |
| Chain | Residue |
| A | HOH2 |
| A | ARG352 |
| B | HOH39 |
| B | ARG352 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ETC A 600 |
| Chain | Residue |
| A | PHE404 |
| A | GLY521 |
| A | HIS524 |
| A | LEU525 |
| A | HOH10 |
| A | LEU346 |
| A | THR347 |
| A | GLU353 |
| A | ARG394 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ETC B 800 |
| Chain | Residue |
| B | HOH48 |
| B | LEU346 |
| B | THR347 |
| B | GLU353 |
| B | LEU387 |
| B | MET388 |
| B | ARG394 |
| B | PHE404 |
| B | ILE424 |
| B | LEU428 |
| B | GLY521 |
| B | HIS524 |
| B | LEU525 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR537 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
