1KLL

Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative

1KLL の概要

• エントリーDOI: 10.2210/pdb1kll/pdb
• 関連するPDBエントリー: 1KMZ
• 分子名称: mitomycin-binding protein, 1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE (3 entities in total)
• 機能のキーワード: mitomycin c, antibiotic resistance, sad, anomalous diffraction, domain swapping, p-staking, antimicrobial protein
• 由来する生物種: Streptomyces lavendulae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14892.19

構造登録者

Martin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U. (登録日: 2001-12-12, 公開日: 2002-07-19, 最終更新日: 2021-10-27)

• 主引用文献: Martin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.H.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U.; Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.; Structure, 10:933-942, 2002; PubMed: 12121648; DOI: 10.1016/S0969-2126(02)00778-5

実験手法

X-RAY DIFFRACTION (1.5 Å)