1KFL

Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from E.coli complexed with Mn2+, PEP, and Phe

Summary for 1KFL

• Entry DOI: 10.2210/pdb1kfl/pdb
• Related: 1GG1 1QR7
• Descriptor: 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: beta/alpha barrel, allosteric inhibition, feedback regulation, aromatic biosynthetic pathway, lyase
• Biological source: Escherichia coli
• Total number of polymer chains: 8
• Total formula weight: 312119.64

Authors

Shumilin, I.A.,Zhao, C.,Bauerle, R.,Kretsinger, R.H. (deposition date: 2001-11-21, release date: 2002-08-23, Last modification date: 2023-11-15)

• Primary citation: Shumilin, I.A.,Zhao, C.,Bauerle, R.,Kretsinger, R.H.; Allosteric inhibition of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase alters the coordination of both substrates.; J.Mol.Biol., 320:1147-1156, 2002; PubMed: 12126632; DOI: 10.1016/S0022-2836(02)00545-4

Experimental method

X-RAY DIFFRACTION (2.8 Å)