1KAK

Human Tyrosine Phosphatase 1B Complexed with an Inhibitor

1KAK の概要

• エントリーDOI: 10.2210/pdb1kak/pdb
• 関連するPDBエントリー: 1KAV
• 分子名称: PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, {[7-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALEN-2-YL]-DIFLUORO-METHYL}-PHOSPHONIC ACID (3 entities in total)
• 機能のキーワード: protein-inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35108.71

構造登録者

Jia, Z.,Ye, Q.,Dinaut, A.N.,Wang, Q.,Waddleton, D.,Payette, P.,Ramachandran, C.,Kennedy, B.,Hum, G.,Taylor, S.D. (登録日: 2001-11-02, 公開日: 2002-06-19, 最終更新日: 2023-08-16)

• 主引用文献: Jia, Z.,Ye, Q.,Dinaut, A.N.,Wang, Q.,Waddleton, D.,Payette, P.,Ramachandran, C.,Kennedy, B.,Hum, G.,Taylor, S.D.; Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.; J.Med.Chem., 44:4584-4594, 2001; PubMed: 11741477; DOI: 10.1021/jm010266w

実験手法

X-RAY DIFFRACTION (2.5 Å)