1K6T

LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE

Summary for 1K6T
Related1K6C 1K6P 1K6V
DescriptorPOL polyprotein, ACETATE ION, N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4-HYDROXY-2-(1-PHENYLETHYL)-PENTANAMIDE, ... (4 entities in total)
Functional Keywordsindinavir, inhibitor recognition, hiv-1 protease, drug resistance, hydrolase
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P35963
Total number of polymer chains2
Total formula weight22527.49
Authors
Schiffer, C.A. (deposition date: 2001-10-17, release date: 2002-02-06, Last modification date: 2011-07-13)
Primary citationGao, Y.,Heefner, D.L.,King, N.M.,Melnick, L.,Nalivaika, E.A.,Nie, X.,Prabu-Jeyabalan, M.,Schiffer, C.A.,Yang, S.S.,Zepp, C.
Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.
Protein Sci., 11:418-429, 2002
PubMed: 11790852
DOI: 110.1110/ps.2520102
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation
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PDB entries from 2021-06-16