1K6T
LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | POL polyprotein | polymer | 99 | 10831.8 | 2 | UniProt (P35963) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C, D, E, F (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 3 | G (B) | N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4-HYDROXY-2-(1-PHENYLETHYL)-PEN TANAMIDE | non-polymer | 627.8 | 1 | Chemie (XN1) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P35963)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
| Arg 14 | Lys 70 | engineered mutation |
| Thr 82 | Val 138 | engineered mutation |
| Val 84 | Ile 140 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21663.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 864.0 | |
| All* | Total formula weight | 22527.5 |
