1K4Y

Crystal Structure of Rabbit Liver Carboxylesterase in Complex with 4-piperidino-piperidine

Summary for 1K4Y

• Entry DOI: 10.2210/pdb1k4y/pdb
• Descriptor: LIVER CARBOXYLESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hydrolase, esterase, side door, camptothecin, irinotecan
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 60529.10

Authors

Bencharit, S.,Morton, C.L.,Howard-Williams, E.L.,Danks, M.K.,Potter, P.M.,Redinbo, M.R. (deposition date: 2001-10-09, release date: 2002-05-01, Last modification date: 2020-07-29)

• Primary citation: Bencharit, S.,Morton, C.L.,Howard-Williams, E.L.,Danks, M.K.,Potter, P.M.,Redinbo, M.R.; Structural insights into CPT-11 activation by mammalian carboxylesterases.; Nat.Struct.Biol., 9:337-342, 2002; PubMed: 11967565; DOI: 10.1038/nsb790

Experimental method

X-RAY DIFFRACTION (2.5 Å)