1K4Y

Crystal Structure of Rabbit Liver Carboxylesterase in Complex with 4-piperidino-piperidine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005811	cellular_component	lipid droplet
A	0016042	biological_process	lipid catabolic process
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0106435	molecular_function	carboxylesterase activity

Functional Information from PROSITE/UniProt

site_id	PS00122
Number of Residues	16
Details	CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpgsVtIfGeSAG

Chain	Residue	Details
A	PHE208-GLY223

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site_id	PS00941
Number of Residues	11
Details	CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIYtP

Chain	Residue	Details
A	GLU114-PRO124

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10039

Chain	Residue	Details
A	SER221

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
A	GLU353
A	HIS467

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3343253

Chain	Residue	Details
A	ASN79
A	ASN389

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qe3

Chain	Residue	Details
A	SER221
A	GLU353
A	HIS467

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