1K4H

CRYSTAL STRUCTURE OF TRNA-GUANINE TRANSGLYCOSYLASE (TGT) COMPLEXED WITH 2,6-Diamino-8-propylsulfanylmethyl-3H-quinazoline-4-one

Summary for 1K4H

• Entry DOI: 10.2210/pdb1k4h/pdb
• Related: 1ENU 1F3E 1K4G 1PUD
• Descriptor: TRNA-GUANINE-TRANSGLYCOSYLASE, ZINC ION, 2,6-DIAMINO-8-PROPYLSULFANYLMETHYL-3H-QUINAZOLINE-4-ONE, ... (4 entities in total)
• Functional Keywords: trna-modifying enzyme, glycosyltransferase, transferase
• Biological source: Zymomonas mobilis
• Total number of polymer chains: 1
• Total formula weight: 43255.46

Authors

Brenk, R.,Meyer, E.A.,Castellano, R.K.,Furler, M.,Stubbs, M.T.,Klebe, G.,Diederich, F. (deposition date: 2001-10-08, release date: 2002-04-24, Last modification date: 2023-08-16)

• Primary citation: Meyer, E.A.,Brenk, R.,Castellano, R.K.,Furler, M.,Klebe, G.,Diederich, F.; De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity.; Chembiochem, 3:250-253, 2002; PubMed: 11921407; DOI: 10.1002/1439-7633(20020301)3:2/3<250::AID-CBIC250>3.0.CO;2-J

Experimental method

X-RAY DIFFRACTION (1.8 Å)