1K2C

Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance

Summary for 1K2C

• Entry DOI: 10.2210/pdb1k2c/pdb
• Related: 1A8K 1A94 1DAZ 1DW6 1K1T 1K1U 1K2B
• Related PRD ID: PRD_000349
• Descriptor: PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
• Functional Keywords: hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• Total number of polymer chains: 2
• Total formula weight: 22288.33

Authors

Mahalingam, B.,Boross, P.,Wang, Y.-F.,Louis, J.M.,Fischer, C.,Tozser, J.,W Harrison, R.,Weber, I.T. (deposition date: 2001-09-26, release date: 2002-07-10, Last modification date: 2023-08-16)

• Primary citation: Mahalingam, B.,Boross, P.,Wang, Y.F.,Louis, J.M.,Fischer, C.C.,Tozser, J.,Harrison, R.W.,Weber, I.T.; Combining mutations in HIV-1 protease to understand mechanisms of resistance.; Proteins, 48:107-116, 2002; PubMed: 12012342; DOI: 10.1002/prot.10140

Experimental method

X-RAY DIFFRACTION (2.2 Å)