1K2C
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEASE RETROPEPSIN | polymer | 99 | 10727.6 | 2 | UniProt (P04587) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | Retropepsin, PR |
| 2 | B | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide | non-polymer | 833.1 | 1 | BIRD (PRD_000349) Chemie (0Q4) | |||
| 3 | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04587)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | SEE REMARK 999 |
| Asn 30 | Asp 530 | engineered mutation |
| Ile 33 | Leu 533 | SEE REMARK 999 |
| Ile 63 | Leu 563 | SEE REMARK 999 |
| Ala 67 | Cys 567 | SEE REMARK 999 |
| Ser 82 | Val 582 | engineered mutation |
| Ala 95 | Cys 595 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21455.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 833.1 | |
| All* | Total formula weight | 22288.3 |
