1K2B
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Summary for 1K2B
Entry DOI | 10.2210/pdb1k2b/pdb |
Related | 1A8K 1A94 1DAZ 1DW6 1K1T 1K1U 1K2C |
Related PRD ID | PRD_000349 |
Descriptor | PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total) |
Functional Keywords | hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22352.45 |
Authors | Mahalingam, B.,Boross, P.,Wang, Y.-F.,Louis, J.M.,Fischer, C.,Tozser, J.,W Harrison, R.,Weber, I.T. (deposition date: 2001-09-26, release date: 2002-07-10, Last modification date: 2023-08-16) |
Primary citation | Mahalingam, B.,Boross, P.,Wang, Y.F.,Louis, J.M.,Fischer, C.C.,Tozser, J.,Harrison, R.W.,Weber, I.T. Combining mutations in HIV-1 protease to understand mechanisms of resistance. Proteins, 48:107-116, 2002 Cited by PubMed: 12012342DOI: 10.1002/prot.10140 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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