1JX7

Crystal structure of ychN protein from E.coli

Summary for 1JX7

• Entry DOI: 10.2210/pdb1jx7/pdb
• Descriptor: HYPOTHETICAL PROTEIN YCHN (2 entities in total)
• Functional Keywords: new fold, hexamer, structural genomics, bsgc structure funded by nih, protein structure initiative, psi, berkeley structural genomics center, unknown function
• Biological source: Escherichia coli
• Total number of polymer chains: 6
• Total formula weight: 77060.23

Authors

Shin, D.H.,Yokota, H.,Kim, R.,Kim, S.-H.,Berkeley Structural Genomics Center (BSGC) (deposition date: 2001-09-05, release date: 2002-09-07, Last modification date: 2024-10-30)

Primary citation

Shin, D.H.,Yokota, H.,Kim, R.,Kim, S.-H.
Crystal structure of a conserved hypothetical protein from Escherichia coli
J.STRUCT.FUNCT.GENOM., 2:53-66, 2002

PubMed Abstract: The crystal structure of a conserved hypothetical protein from Escherichia coli has been determined using X-ray crystallography. The protein belongs to the Cluster of Orthologous Group COG1553 (National Center for Biotechnology Information database, NLM, NIH), for which there was no structural information available until now. Structural homology search with DALI algorism indicated that this protein has a new fold with no obvious similarity to those of other proteins with known three-dimensional structures. The protein quaternary structure consists of a dimer of trimers, which makes a characteristic cylinder shape. There is a large closed cavity with approximate dimensions of 16 A x 16 A x 20 A in the center of the hexameric structure. Six putative active sites are positioned along the equatorial surface of the hexamer. There are several highly conserved residues including two possible functional cysteines in the putative active site. The possible molecular function of the protein is discussed.

PubMed: 12836674
DOI: 10.1023/A:1014450817696

Experimental method

X-RAY DIFFRACTION (2.8 Å)