HCMV protease dimer-interface mutant, S225Y complexed to Inhibitor BILC 408

Summary for 1JQ7

Related1WPO 2WPO 1JQ6
Related PRD IDPRD_000283
DescriptorASSEMBLIN, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (2 entities in total)
Functional Keywordsherpesvirus, cytomegalovirus, serine protease, dimerization, enzyme activity regulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman herpesvirus 5 (Human cytomegalovirus)
Cellular locationProtease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus P16753
Total number of polymer chains2
Total molecular weight57849.16
Batra, R.,Khayat, R.,Tong, L. (deposition date: 2001-08-03, release date: 2001-09-12, Last modification date: 2012-12-12)
Primary citation
Batra, R.,Khayat, R.,Tong, L.
Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease.
Nat.Struct.Biol., 8:810-817, 2001
PubMed: 11524687 (PDB entries with the same primary citation)
DOI: 10.1038/nsb0901-810
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers449.2%9.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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