1JQ7
HCMV protease dimer-interface mutant, S225Y complexed to Inhibitor BILC 408
Summary for 1JQ7
Entry DOI | 10.2210/pdb1jq7/pdb |
Related | 1JQ6 1WPO 2WPO |
Related PRD ID | PRD_000283 |
Descriptor | ASSEMBLIN, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (2 entities in total) |
Functional Keywords | herpesvirus, cytomegalovirus, serine protease, dimerization, enzyme activity regulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human herpesvirus 5 (Human cytomegalovirus) |
Cellular location | Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753 |
Total number of polymer chains | 2 |
Total formula weight | 57849.16 |
Authors | Batra, R.,Khayat, R.,Tong, L. (deposition date: 2001-08-03, release date: 2001-09-12, Last modification date: 2024-03-13) |
Primary citation | Batra, R.,Khayat, R.,Tong, L. Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nat.Struct.Biol., 8:810-817, 2001 Cited by PubMed: 11524687DOI: 10.1038/nsb0901-810 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report