1JQ7

HCMV protease dimer-interface mutant, S225Y complexed to Inhibitor BILC 408

Summary for 1JQ7

Entry DOI	10.2210/pdb1jq7/pdb
Related	1JQ6 1WPO 2WPO
Related PRD ID	PRD_000283
Descriptor	ASSEMBLIN, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (2 entities in total)
Functional Keywords	herpesvirus, cytomegalovirus, serine protease, dimerization, enzyme activity regulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human herpesvirus 5 (Human cytomegalovirus)
Cellular location	Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753
Total number of polymer chains	2
Total formula weight	57849.16
Authors	Batra, R.,Khayat, R.,Tong, L. (deposition date: 2001-08-03, release date: 2001-09-12, Last modification date: 2024-03-13)
Primary citation	Batra, R.,Khayat, R.,Tong, L. Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nat.Struct.Biol., 8:810-817, 2001 Cited by PubMed: 11524687 DOI: 10.1038/nsb0901-810 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation