1JQ7

HCMV protease dimer-interface mutant, S225Y complexed to Inhibitor BILC 408

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ASSEMBLIN	polymer	256	28206.6	2	UniProt (P16753) Pfam (PF00716) In PDB	Human herpesvirus 5 (Human cytomegalovirus)	PROTEASE
2	A, B	N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide	non-polymer		717.9	2	BIRD (PRD_000283) Chemie (0FP)

Sequence modifications

A, B: 1001 - 1256 (UniProt: P16753)

PDB	External Database	Details
Gln 1143	Ala 143	engineered mutation
Tyr 1225	Ser 225	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56413.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1435.9
All*	Total formula weight	57849.2

*Water molecules are not included.