1JOL
THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE
Summary for 1JOL
| Entry DOI | 10.2210/pdb1jol/pdb |
| Descriptor | DIHYDROFOLATE REDUCTASE, CHLORIDE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (5 entities in total) |
| Functional Keywords | methotrexate resistance, one-carbon metabolism, oxidoreductase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 2 |
| Total formula weight | 37098.51 |
| Authors | Lee, H.,Reyes, V.M.,Kraut, J. (deposition date: 1996-02-25, release date: 1996-11-08, Last modification date: 2024-02-07) |
| Primary citation | Lee, H.,Reyes, V.M.,Kraut, J. Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4. Biochemistry, 35:7012-7020, 1996 Cited by PubMed: 8679526DOI: 10.1021/bi960028g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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