1JOL
THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DIHYDROFOLATE REDUCTASE | polymer | 159 | 18020.3 | 2 | UniProt (P0ABQ4) Pfam (PF00186) | Escherichia coli | 5,6,7,8-TETRAHYDROFOLATE\: 2 NADP+ OXIDOREDUCTASE |
| 2 | C, E (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D, G (A, B) | N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid | non-polymer | 473.4 | 2 | Chemie (FFO) | |||
| 4 | F (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 427 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Asp 37 | Asn 37 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36040.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1057.9 | |
| All* | Total formula weight | 37098.5 |
