1JNK

THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP

Summary for 1JNK

• Entry DOI: 10.2210/pdb1jnk/pdb
• Descriptor: C-JUN N-TERMINAL KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: transferase, jnk3 map kinase, serine/threonine protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P53779
• Total number of polymer chains: 1
• Total formula weight: 49116.82

Authors

Xie, X.,Su, M.S.-S. (deposition date: 1998-06-03, release date: 1999-06-08, Last modification date: 2024-02-07)

Primary citation

Xie, X.,Gu, Y.,Fox, T.,Coll, J.T.,Fleming, M.A.,Markland, W.,Caron, P.R.,Wilson, K.P.,Su, M.S.
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.
Structure, 6:983-991, 1998

PubMed Abstract: The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. Activation and nuclear localization of JNK3, a neuronal-specific isoform of JNK, has been associated with hypoxic and ischemic damage of CA1 neurons in the hippocampus. Knockout mice lacking JNK3 showed reduced apoptosis of hippocampal neurons and reduced seizure induced by kainic acid, a glutamate-receptor agonist. Thus, JNK3 may be important in the pathology of neurological disorders and is of significant medical interest.

PubMed: 9739089
DOI: 10.1016/S0969-2126(98)00100-2

Experimental method

X-RAY DIFFRACTION (2.3 Å)