1JNK

THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP

1JNK の概要

• エントリーDOI: 10.2210/pdb1jnk/pdb
• 分子名称: C-JUN N-TERMINAL KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: transferase, jnk3 map kinase, serine/threonine protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49116.82

構造登録者

Xie, X.,Su, M.S.-S. (登録日: 1998-06-03, 公開日: 1999-06-08, 最終更新日: 2024-02-07)

主引用文献

Xie, X.,Gu, Y.,Fox, T.,Coll, J.T.,Fleming, M.A.,Markland, W.,Caron, P.R.,Wilson, K.P.,Su, M.S.
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.
Structure, 6:983-991, 1998

PubMed Abstract: The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. Activation and nuclear localization of JNK3, a neuronal-specific isoform of JNK, has been associated with hypoxic and ischemic damage of CA1 neurons in the hippocampus. Knockout mice lacking JNK3 showed reduced apoptosis of hippocampal neurons and reduced seizure induced by kainic acid, a glutamate-receptor agonist. Thus, JNK3 may be important in the pathology of neurological disorders and is of significant medical interest.

PubMed: 9739089
DOI: 10.1016/S0969-2126(98)00100-2

実験手法

X-RAY DIFFRACTION (2.3 Å)