1JMJ

Crystal Structure of Native Heparin Cofactor II

Summary for 1JMJ

• Entry DOI: 10.2210/pdb1jmj/pdb
• Related: 1JMO
• Descriptor: HEPARIN COFACTOR II, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: serpin, thrombin inhibitor, heparin, blood clotting
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 110901.50

Authors

Baglin, T.P.,Carrell, R.W.,Church, F.C.,Huntington, J.A. (deposition date: 2001-07-18, release date: 2002-08-30, Last modification date: 2024-04-03)

• Primary citation: Baglin, T.P.,Carrell, R.W.,Church, F.C.,Esmon, C.T.,Huntington, J.A.; Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.; Proc.Natl.Acad.Sci.USA, 99:11079-11084, 2002; PubMed: 12169660; DOI: 10.1073/pnas.162232399

Experimental method

X-RAY DIFFRACTION (2.35 Å)