1JMJ
Crystal Structure of Native Heparin Cofactor II
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0006935 | biological_process | chemotaxis |
| A | 0007596 | biological_process | blood coagulation |
| A | 0007599 | biological_process | hemostasis |
| A | 0008201 | molecular_function | heparin binding |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0006935 | biological_process | chemotaxis |
| B | 0007596 | biological_process | blood coagulation |
| B | 0007599 | biological_process | hemostasis |
| B | 0008201 | molecular_function | heparin binding |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00284 |
| Number of Residues | 11 |
| Details | SERPIN Serpins signature. FTVDRPFLFlI |
| Chain | Residue | Details |
| A | PHE450-ILE460 |
| site_id | PS00430 |
| Number of Residues | 85 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. gskgpldqlekggetaqsadpqweqlnnknlsmpllpadfhkentvtndwipegeedddyldlekifsedddyidiv......................................DSLSVSPT |
| Chain | Residue | Details |
| A | GLY1-THR85 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Region: {"description":"Glycosaminoglycan-binding site"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Reactive bond","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12169660","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12169660","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
