1JL0
Structure of a Human S-Adenosylmethionine Decarboxylase Self-processing Ester Intermediate and Mechanism of Putrescine Stimulation of Processing as Revealed by the H243A Mutant
Summary for 1JL0
Entry DOI | 10.2210/pdb1jl0/pdb |
Related | 1JEN |
Descriptor | S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME, 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | spermidine biosynthesis, lyase, decarboxylase, pyruvate, s-adenosylmethionine, sandwich, allosteric enzyme, pyruvoyl, ester intermediate, hydroxyalanine |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 77017.49 |
Authors | Ekstrom, J.L.,Tolbert, W.D.,Xiong, H.,Pegg, A.E.,Ealick, S.E. (deposition date: 2001-07-13, release date: 2001-08-22, Last modification date: 2023-08-16) |
Primary citation | Ekstrom, J.L.,Tolbert, W.D.,Xiong, H.,Pegg, A.E.,Ealick, S.E. Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant. Biochemistry, 40:9495-9504, 2001 Cited by PubMed: 11583148DOI: 10.1021/bi010736o PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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