1JL0

Structure of a Human S-Adenosylmethionine Decarboxylase Self-processing Ester Intermediate and Mechanism of Putrescine Stimulation of Processing as Revealed by the H243A Mutant

1JL0 の概要

• エントリーDOI: 10.2210/pdb1jl0/pdb
• 関連するPDBエントリー: 1JEN
• 分子名称: S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME, 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: spermidine biosynthesis, lyase, decarboxylase, pyruvate, s-adenosylmethionine, sandwich, allosteric enzyme, pyruvoyl, ester intermediate, hydroxyalanine
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77017.49

構造登録者

Ekstrom, J.L.,Tolbert, W.D.,Xiong, H.,Pegg, A.E.,Ealick, S.E. (登録日: 2001-07-13, 公開日: 2001-08-22, 最終更新日: 2023-08-16)

• 主引用文献: Ekstrom, J.L.,Tolbert, W.D.,Xiong, H.,Pegg, A.E.,Ealick, S.E.; Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant.; Biochemistry, 40:9495-9504, 2001; PubMed: 11583148; DOI: 10.1021/bi010736o

実験手法

X-RAY DIFFRACTION (1.5 Å)